Depends. If you are running shimano 10 speed only wheels, then no - but this isn't very likely, only shimano made a few such wheels and even they have given up on the 10 speed only.
If you run wheels that are shimano 9/10 or SRAM compatible, no problem. You can check this by removing the CS5600. If there is a spacer washer you have a wheel that will take the sram cassette.